This project was directed at identifying new biologically active substances, so called lead
structures, for the development of drugs by analyzing data pools, such as data bases of
molecules, and in particular data bases of naturally occurring molecules.
In the last years, naturally occurring molecules experienced a comeback in drug development.
As a result of this comeback different authors have suggested to combine structural elements of
interest and have broken down molecules into their base elements. However, these
approaches often stalled in view of the sheer complexity of possible combinations. Accordingly,
the relatively few tested structures often did not show the desired effect.
Thus, there is a need for a method and system that provides substructures of molecules,
particularly, of naturally occurring molecules (“host molecules”)
with a higher degree of selectivity, that is, with a higher potential of containing or constituting
lead drug structures.
Patent:
Provisional Application
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Inventor
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T. Wilhelm & M. Friedel
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Title
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Lead Structures for Drugs
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Appl. No.
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60/829,894
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This project was a collaboration with Dr. Thomas Wilhelm and is now one of his main topics at his new systems biology group in England. If you want to know more
please visit his homepage: Dr. Thomas Wilhelm (IFR Norwich, UK).
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